26-month Guarantee

Luxe Labradors™ guarantees, for 26-months, that the puppy will not be affected by the following conditions:

 

EIC: Exercise-Induced Collapse

DM: Degenerative Myelopathy

CNM: Centronuclear Myopathy

PRA/PRCD: Progressive Retinal Atrophy

RD/OSD: Retinal Dysplasia-retinal folds

HNPK: Hereditary Nasal Parakeratosis

 

The parents of the puppy have been DNA tested and cleared for these diseases.  Here is an explanation of each.

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EIC stands for Exercise-Induced Collapse.  It is a devastating genetic disorder causing the affected dog to suffer from loss of muscle control following extreme exercise.  This disorder is caused by a mutation in the Dyamin 1 gene.  Because EIC is a recessive disorder, a dog must have two copies of the mutation in order for the disease to manifest itself.  Typically an affected dog begins to show symptoms between 5 months and 3 years of age.

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DM stands for Degenterative Myelopathy.  It is a progressive disease, meaning that dogs slowly grow weaker and weaker over a four to six month period of time following the diagnosis.  DM usually affects the hind legs first, but muscle weakness can spread to the front legs as well.  Dogs with DM may begin to stumble frequently as they become progressively weaker due to nerve damage.  Eventually, dogs with DM will lose control of their bladder and bowels.  As the disease moves into the final stages, symptoms of weakness, trembling and stumbling will begin to affect the front legs as well. 

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CNM stands for Centronuclear Myopathy.  Puppies are born apparently normal; however, it quickly becomes evident that there is a problem.  The puppy will often not gain weight due to decreased muscle tone in the esophagus.  By age two to 5 months the disease has usually progressed to display the full range of symptoms, including a loss of muscle tone and control, an awkward gait and extreme exercise intolerance.  This condition gets worse in cold climates.  There is not a cure CNM.

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PRA stands for Progressive Retinal Atrophy.  It is a general term for the group of diseases causing degeneration of the retina, leading to loss of vision.  The form of this disorder in labradors is PRCD (Progressive Rod-Cone Degeneration).  This leads to the first loss of night vision and then to complete vision loss of the dog.  The typical onset for this is between 3 and 5 years of age.  

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RD/OSD stands for Retinal Dysplasia-retinal folds.  Retinal folds can cause blindness in a dog if not corrected by surgery.  OSD (OculoSkeletal Dysplasia) is a serious inherited syndrome that causes severe condition in which the dogs show a variety of skeletal malformations, including shortened limbs (dwarfism), and blindness at an early age; the blindness results from a generalized malformation of the retina that causes a partial or full retinal detachment and cataracts.

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HNPK stands for Hereditary Nasal Parakeratosis.  It is an inherited autosomal recessive disorder in Labrador retrievers.  A mutation T>G in the SUV39H2 gene causes the nose to dry out leading to chronic irritation and inflammation of the skin in the nose.  Symptoms of the disorder generally appear around 6-12 months of age.  Affected dogs develop dry, rough, gray to brown crust on the surface and edge of the nose.  In some cases, painful cracks around and on the tip of the nose develop and if not treated develop superficial bacterial infections.

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